The film details the personal experiences of five young Western men who were identified in childhood as being tulkus, or reincarnated Tibetan Buddhist masters.

Brilliant Moon chronicles the life of the writer, poet, and meditation master Khyentse Rinpoche, one of Tibet's most revered 20th-century Buddhist teachers. Spiritual guide to His Holiness the Dalai Lama and the Royal Family of Bhutan, his life and teachings were an inspiration to all who encountered him. Richard Gere and Lou Reed provide the narration for his dangerous journey out of China, the subsequent spread of his influence and the search for his reincarnation after his death.